Publications from riboxx´s scientists


Geissler K, Eschen-Lippold L, Naumann K, Schneeberger K, Weigel D, Scheel D, Rosahl S, Westphal L. Mutations in the EDR1 Gene Alter the Response of Arabidopsis thaliana to Phytophthora infestans and the Bacterial PAMPs flg22 and elf18. Mol Plant Microbe Interact. 2015 Feb;28(2):122-33.


Croci R, Tarantino D, Milani M, Pezzullo M, Rohayem J, Bolognesi M, Mastrangelo E. PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. FEBS Lett. 2014 May 2;588(9):1720-5.

Mastrangelo E, Mazzitelli S, Fabbri J, Rohayem J, Ruokolainen J, Nykänen A, Milani M, Pezzullo M, Nastruzzi C, Bolognesi M. Delivery of Suramin as an Antiviral Agent through Liposomal Systems. ChemMedChem. 2014 May;9(5):933-9.

Croci R, Pezzullo M, Tarantino D, Milani M, Tsay SC, Sureshbabu R, Tsai YJ, Mastrangelo E, Rohayem J, Bolognesi M, Hwu JR. Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. PLoS One. 2014 Mar 12;9(3):e91765.

Tarantino D, Pezzullo M, Mastrangelo E, Croci R, Rohayem J, Robel I, Bolognesi M, Milani M. Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase. Antiviral Res. 2014 Feb;102:23-8.


Naumann K, Wehner R, Schwarze A, Petzold C, Schmitz M, Rohayem J. Activation of Dendritic Cells by the Novel Toll-Like Receptor 3 Agonist RGC100. Clinical and Developmental Immunol. 2013 Oct 29.

Barral K, Sallamand C, Petzold C, Coutard B, Collet A, Thillier Y, Zimmermann J, Vasseur JJ, Canard B, Rohayem J, Debart F, Decroly E. Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening. Antiviral Res. 2013 Sep;99(3):292-300.

Jähnisch H, Wehner R, Tunger A, Kunze A, Oehrl S, Schäkel K, Rohayem J, Bornhäuser M, Tonn T, Bachmann M, Schmitz M. TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells. Cancer Lett. 2013 Feb 9.

Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.


Mastrangelo E, Pezzullo M, Tarantino D, Petazzi R, Germani F, Kramer D, Robel  I, Rohayem J, Bolognesi M, Milani M. Structure-based inhibition of Norovirus RNA-dependent RNA polymerases. J Mol Biol. 2012 Jun 8;419(3-4):198-210.


Rohayem J, Bergmann M, Gebhardt J, Gould E, Tucker P, Mattevi A, Unge T, Hilgenfeld R, Neyts J. Antiviral strategies to control calicivirus infections. Antiviral Res. 2010 Aug; 87(2): 162-78.


Rohayem J. Norovirus seasonality and the potential impact of climate change. Clin Microbiol Infect. 2009 Jun; 15(6): 524-7.

Speroni S, Rohayem J, Nenci S, Bonivento D, Robel I, Barthel J, Luzhkov VB,Coutard B, Canard B, Mattevi A. Structural and biochemical analysis of human pathogenic astrovirus serine protease at 2.0 A resolution. J Mol Biol. 2009 Apr 17;387(5):1137-52.

Högbom M, Jäger K, Robel I, Unge T, Rohayem J. The active form of the norovirus RNA-dependent RNA polymerase is a homodimer with cooperative activity. J Gen Virol. 2009 Feb;90(Pt 2):281-91.


Robel I, Gebhardt J, Mesters JR, Gorbalenya A, Coutard B, Canard B, Hilgenfeld R, Rohayem J. Functional characterization of the cleavage specificity of the sapovirus chymotrypsin-like protease. J Virol. 2008 Aug;82(16):8085-93.

De Palma AM, Heggermont W, Lanke K, Coutard B, Bergmann M, Monforte AM, Canard B, De Clercq E, Chimirri A, Pürstinger G, Rohayem J, van Kuppeveld F, Neyts J. The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C. J Virol. 2008 May;82(10):4720-30.

Müller R, Ditzen A, Hille K, Stichling M, Ehricht R, Illmer T, Ehninger G, Rohayem J. Detection of herpesvirus and adenovirus co-infections with diagnostic DNA-microarrays. J Virol Methods. 2009 Feb;155(2):161-6.


Coutard B, Gorbalenya AE, Snijder EJ, Leontovich AM, Poupon A, De Lamballerie X, Charrel R, Gould EA, Gunther S, Norder H, Klempa B, Bourhy H, Rohayem J,L'hermite E, Nordlund P, Stuart DI, Owens RJ, Grimes JM, Tucker PA, Bolognesi M, Mattevi A, Coll M, Jones TA, Aqvist J, Unge T, Hilgenfeld R, Bricogne G, Neyts J, La Colla P, Puerstinger G, Gonzalez JP, Leroy E, Cambillau C, Romette JL, Canard B. The VIZIER project: preparedness against pathogenic RNA viruses. Antiviral Res. 2008 Apr;78(1):37-46.

Pöhlmann C, Hochauf K, Röllig C, Schetelig J, Wunderlich O, Bandt D, Ehninger G, Jacobs E, Rohayem J. Chlorpromazine combined with cidofovir for treatment of a patient suffering from progressive multifocal leukoencephalopathy. Intervirology. 2007;50(6):412-7.

Pöhlmann C, Schetelig J, Reuner U, Bornhäuser M, Illmer T, Kiani A, Ehninger G, Jacobs E, Rohayem J. Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient. Clin Infect Dis. 2007 Jun 15;44(12):e118-20.

Scheffler U, Rudolph W, Gebhardt J, Rohayem J. Differential cleavage of the norovirus polyprotein precursor by two active forms of the viral protease. J Gen Virol. 2007 Jul;88(Pt 7):2013-8.


Fullerton SW, Blaschke M, Coutard B, Gebhardt J, Gorbalenya A, Canard B,Tucker PA, Rohayem J. Structural and functional characterization of sapovirus RNA-dependent RNA polymerase. J Virol. 2007 Feb;81(4):1858-71.

Sassenscheidt J, Rohayem J, Illmer T, Bandt D. Detection of beta-herpesviruses in allogenic stem cell recipients by quantitative real-time PCR. J Virol Methods. 2006 Dec;138(1-2):40-8.

Rohayem J, Dumke R, Jaeger K, Schröter-Bobsin U, Mogel M, Kruse A, Jacobs E, Rethwilm A. Assessing the risk of transmission of viral diseases in flooded areas: viral load of the River Elbe in Dresden during the flood of August 2002. Intervirology. 2006;49(6):370-6.

Rohayem J, Jäger K, Robel I, Scheffler U, Temme A, Rudolph W. Characterization of norovirus 3Dpol RNA-dependent RNA polymerase activity and initiation of RNA synthesis. J Gen Virol. 2006 Sep;87(Pt 9):2621-30.

Rohayem J, Robel I, Jäger K, Scheffler U, Rudolph W. Protein-primed and de novo initiation of RNA synthesis by norovirus 3Dpol. J Virol. 2006 Jul;80(14):7060-9.


Rohayem J, Münch J, Rethwilm A. Evidence of recombination in the norovirus capsid gene. J Virol. 2005 Apr;79(8):4977-90.


Rohayem J, Berger S, Juretzek T, Herchenröder O, Mogel M, Poppe M, Henker J, Rethwilm A. A simple and rapid single-step multiplex RT-PCR to detect Norovirus, Astrovirus and Adenovirus in clinical stool samples. J Virol Methods. 2004 Jun 1;118(1):49-59.

Rieger MA, Ebner R, Bell DR, Kiessling A, Rohayem J, Schmitz M, Temme A, Rieber EP, Weigle B. Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. Cancer Res. 2004 Apr 1;64(7):2357-64.


Temme A, Morgenroth A, Schmitz M, Weigle B, Rohayem J, Lindemann D, Füssel M, Ehninger G, Rieber EP. Efficient transduction and long-term retroviral expression of the melanoma-associated tumor antigen tyrosinase in CD34(+) cord blood-derived dendritic cells. Gene Ther. 2002 Nov;9(22):1551-60.

Schmitz M, Rohayem J, Paul R, Weigle B, Stein A, Rieber EP. Quantification of antigen-reactive T cells by a modified ELISPOT assay based on freshly isolated blood dendritic cells. J Clin Lab Anal. 2002;16(1):30-6.


Rohayem J, Dinger J, Fischer R, Klingel K, Kandolf R, Rethwilm A. Fatal myocarditis associated with acute parvovirus B19 and human herpesvirus 6 coinfection. J Clin Microbiol. 2001 Dec;39(12):4585-7.


Rohayem J, Diestelkoetter P, Weigle B, Oehmichen A, Schmitz M, Mehlhorn J, Conrad K, Rieber EP. Antibody response to the tumor-associated inhibitor of apoptosis protein survivin in cancer patients. Cancer Res. 2000 Apr 1;60(7):1815-7.


Rohayem J, Conrad K, Zimmermann T, Frank KH. Comparison of the diagnostic accuracy of three commercially available enzyme immunoassays for anti-p53 antibodies. Clin Chem. 1999 Nov;45(11):2014-6

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