iBONi siRNA quattro

€443.00
SKU
D-00103

To order the iBONi siRNA quattro, please enter the Gene ID (NCBI)

Set of 4 siRNAs for gene knockdown
3 x pre-designed iBONi siRNA
1 x iBONi siRNA negative control

Amount: 2 or 5 nmol each
Purification: RP/SEC
Quality control: PAGE
Delivery: dried

iBONi siRNA displays a new technology invented at Riboxx, the RNAi-cap.

The RNAi-cap technology offers several advantages:

  • directional modulation of RISC unwinding of siRNA duplex, enhancing loading of the guide strand to the RISC complex. As a consequence, much less siRNA are needed for an effective gene silencing with a subsequent reduction of off-target effects [1]
  • improved stability of siRNA duplex with subsequent improved half-life in body fluids.

References
[1] Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.

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iBONi siRNA : your gene knockdown bonus
iBONi siRNA quattro : instructions of use

Application notes

Most recent citations

Totta P et al. Mol Endocrinol. 2015 May;29(5):739-55.
Nabissi M et al. Int J Cancer. 2015 Apr 22.
Cottone L et al. Int J Cancer. 2015 Mar 15;136(6):1381-9.
Schomaker M et al. J Nanobiotechnology. 2015 Feb 3;13(1):10.
Bremmer F et al. SpringerPlus. 2014 Oct. (3):574.
Knoch KP et al. Mol Metab. 2014 May 14;3(5):518-30.
Fliedl L et al. ALTEX. 2014;31(3):269-78.
Sanità P et al. BMC Cancer. 2014 Mar 5;14:154.
Garulli C et al. Cell Signal. 2014 Feb;26(2):352-62.
Schneider H et al. Tissue Eng Part A. 2014 Jan;20(1-2):335-45.
Cheng X et al. Bioorg Med Chem. 2014 Jan 1;22(1):247-55.

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