iBONi siRNA pool

€288.00
SKU
D-00101

To order the iBONi siRNA pool, please enter the Gene ID (NCBI)

Mix of 3 x pre-designed siRNA for gene knockdown

Total siRNA amount: 5 or 10 nmol
Purification: RP/SEC
Quality control: PAGE
Delivery: dried

iBONi siRNA pool is a mixture of 3 x pre-designed siRNAs targeting the same gene. The IBONi siRNA pool provides a simple and cost-effective way to perform a highly effective and specific gene silencing. With the iBONi siRNA pool, Riboxx will provide the sequence information of the siRNA.

iBONi siRNA displays the RNAi-cap, a new technology invented at Riboxx. The RNAi-cap technology offers several advantages:

  • directional modulation of RISC unwinding of siRNA duplex, enhancing loading of the guide strand to the RISC complex. As a consequence, much less siRNA are needed for an effective gene silencing with a subsequent reduction of off-target effects [1]
  • improved stability of siRNA duplex with subsequent improved half-life in body fluids.

References
[1] Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.

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iBONi siRNA pool

Application notes

Most recent citations

Nabissi M et al. Int J Cancer. 2015 Apr 22.
Krossa S et al. Oncotarget. 2015 Apr 18.
Laurenzana A et al. J Mol Med (Berl). 2015 Feb 20.
Troiano A et al. J Cell Physiol. 2015 Jan 29.
Palumbo S et al. J Cell Physiol. 2014 Nov;229(11):1863-73
Galletti M et al. Biochem Pharmacol. 2014 Sep 15;91(2):181-90.
Gangemi R et al. Pigment Cell Melanoma Res. 2014 Aug 14.
Puddu A et al. Mediators Inflamm. 2013 Apr.

 

 

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