iBONi siRNA pool
Mix of 3 x pre-designed siRNA for gene knockdown
Total siRNA amount: 5 or 10 nmol
Quality control: PAGE
iBONi siRNA pool is a mixture of 3 x pre-designed siRNAs targeting the same gene. The IBONi siRNA pool provides a simple and cost-effective way to perform a highly effective and specific gene silencing. With the iBONi siRNA pool, Riboxx will provide the sequence information of the siRNA.
iBONi siRNA displays the RNAi-cap, a new technology invented at Riboxx. The RNAi-cap technology offers several advantages:
- directional modulation of RISC unwinding of siRNA duplex, enhancing loading of the guide strand to the RISC complex. As a consequence, much less siRNA are needed for an effective gene silencing with a subsequent reduction of off-target effects 
- improved stability of siRNA duplex with subsequent improved half-life in body fluids.
 Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.
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Most recent citations
Nabissi M et al. Int J Cancer. 2015 Apr 22.