iBONi siRNA plus

€221.00
SKU
D-00105

To order iBONi siRNA plus, please enter the target sequence of siRNA (passenger strand, 19 - 25 nt in length). Valid inputs are: 'G'; 'C'; 'A'; 'U'; 'g'; 'c'; 'a'; 'u'

Maximum number of characters: 25

Set of 2 siRNAs for gene knockdown
• 1 x custom iBONi siRNA
• 1 x iBONi siRNA negative control

Amount: 2 or 5 nmol each
Purification: RP/SEC
Quality control: PAGE
Delivery: dried

iBONi siRNA displays a new technology invented at Riboxx, the RNAi-cap.
The RNAi-cap technology offers several advantages:

  • directional modulation of RISC unwinding of siRNA duplex, enhancing loading of the guide strand to the RISC complex. As a consequence, much less siRNA are needed for an effective gene silencing with a subsequent reduction of off-target effects [1]
  • improved stability of siRNA duplex with subsequent improved half-life in body fluids.

References
[1] Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.

More Information
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iBONi siRNA : your gene knockdown bonus

Application notes

Most recent citations

Saalbach A et al. Exp Dermatol. 2015 Apr 11.
Krossa S et al. Oncotarget. 2015 Apr 18.
Nehls J et al. PLoS One. 2014 Aug 15;9(8):e105478.
Cottone L et al. Int J Cancer. 2015 Mar 15;136(6):1381-9.

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