CONmiR mimic
€124.00
SKU
M-00202
1 x pre-designed CONmiR mimic for gene knockdown
Amount: 2, 5 or 10 nmol each
Purification: RP/SEC
Quality control: PAGE
Delivery: dried

CONmiR mimics display the RNAi-cap, a new technology invented at Riboxx. The RNAi-cap technology offers several advantages:
- directional modulation of RISC unwinding of miRNA duplex, enhancing loading of the guide strand to the RISC complex. As a consequence, much less miRNA is needed for an effective gene silencing with a subsequent reduction of off-target effects [1]
- improved stability of miRNA duplex with subsequent improved half-life in body fluids.
References
[1] Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.
Desc 2 | Download the flyerCONmiR miRNA mimics with gene knockdown bonus Application notes
Most recent citationsParsi S et al. Mol Ther Nucleic Acids. 2015 Oct 6. |
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