CONmiR mimic

€124.00

SKU

M-00202

To order CONmiR mimic, please enter the sequence of mature miRNA
(5p- or 3p-, 19 - 25 nt in length, valid inputs are: 'G'; 'C'; 'A'; 'U'; 'g'; 'c'; 'a'; 'u')

CONmiR miRNA name

seq:5'|3'

Maximum number of characters: 25

Amount

Qty

1 x pre-designed CONmiR mimic for gene knockdown

Amount: 2, 5 or 10 nmol each
Purification: RP/SEC
Quality control: PAGE
Delivery: dried

Details

CONmiR mimics display the RNAi-cap, a new technology invented at Riboxx. The RNAi-cap technology offers several advantages:

directional modulation of RISC unwinding of miRNA duplex, enhancing loading of the guide strand to the RISC complex. As a consequence, much less miRNA is needed for an effective gene silencing with a subsequent reduction of off-target effects [1]
improved stability of miRNA duplex with subsequent improved half-life in body fluids.

References
[1] Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.

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Inhaltsstoffe

More Information

More Information
Desc 2	Download the flyer CONmiR miRNA mimics with gene knockdown bonus Application notes potent miRNA mimics with the RNAi-cap potent and specific knockdown with the RNAi-cap siRNA and miRNA mimics with the RNAi-cap are resistant to serum degradation longer and better gene knockdown with the RNAi-cap potent gene knockdown in VIVO with the RNAi-cap Most recent citations Parsi S et al. Mol Ther Nucleic Acids. 2015 Oct 6. Smith PY et al. Hum Mol Genet. 2015 Dec 1. Dusl M et al. Hum Mol Genet. 2015 Mar 12. Porstner M et al. Eur J Immunol. 2015 Apr. Tatikotta SG. Freie Universität Berlin, 2015.

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CONmiR mimic

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