CONmiR mimic in vivo
1 x pre-designed CONmiR mimic for IN VIVO gene knockdown
Amount: 20, 100, 200 or 500 nmol
Quality control: IEX HPLC
In vivo grade: desalted, endotoxin-free
CONmiR mimic in vivo is a hybrid of the mature microRNA sequence and its complementary sequence, assembling in a RNA duplex for gene knockdown in vivo. Provided with the RNAi-cap technology, the CONmiR mimic display increased potency and serum stability.
The RNAi-cap technology offers several advantages:
- directional modulation of RISC unwinding of miRNA duplex, enhancing loading of the guide strand to the RISC complex. As a consequence, much less miRNA is needed for an effective gene silencing with a subsequent reduction of off-target effects 
- improved stability of miRNA duplex with subsequent improved half-life in body fluids.
 Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.
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Most recent citations
Parsi S et al. Mol Ther Nucleic Acids. 2015 Oct 6.