CONmiR mimic in vivo

€556.00
SKU
M-00303

To order CONmiR mimic in vivo, please enter the sequence of mature miRNA
(5p- or 3p-, 19 - 25 nt in length, valid inputs are: 'G'; 'C'; 'A'; 'U'; 'g'; 'c'; 'a'; 'u')

1 x pre-designed CONmiR mimic for IN VIVO gene knockdown

Amount: 20, 100, 200 or 500 nmol
Purification:
RP/IEX-HPLC
Quality control: IEX HPLC
In vivo grade: desalted, endotoxin-free
Delivery: dried

CONmiR mimic in vivo is a hybrid of the mature microRNA sequence and its complementary sequence, assembling in a RNA duplex for gene knockdown in vivo. Provided with the RNAi-cap technology, the CONmiR mimic display increased potency and serum stability.

The RNAi-cap technology offers several advantages:

  • directional modulation of RISC unwinding of miRNA duplex, enhancing loading of the guide strand to the RISC complex. As a consequence, much less miRNA is needed for an effective gene silencing with a subsequent reduction of off-target effects [1]
  • improved stability of miRNA duplex with subsequent improved half-life in body fluids.

References
[1] Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.

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CONmiR miRNA mimics with gene knockdown bonus

Application notes

Most recent citations

Parsi S et al. Mol Ther Nucleic Acids. 2015 Oct 6.
Smith PY et al. Hum Mol Genet. 2015 Dec 1.
Dusl M et al. Hum Mol Genet. 2015 Mar 12.
Porstner M et al. Eur J Immunol. 2015 Apr.
Tatikotta SG. Freie Universität Berlin, 2015.

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