CONmiR mimic box
All-in-one solution for gene knockdown
1 x pre-designed CONmiR mimic
1 x CONmiR mimic negative control
1 x riboxxFECT transfection reagent
miRNA amount: 2 or 5 nmol each
Quality control: PAGE
Transfection reagent: 250 µl
In order to make gene knockdown experiments easier and more effective, Riboxx offers the CONmiR mimic box. The CONmiR mimic box is a powerful all-in-one solution with a package of perfectly matched tools for every step of gene knockdown experiments. It includes 1 x pre-designed CONmiR mimic, 1x CONmiR mimic negative control, and riboxxFECT transfection reagent.
CONmiR mimic displays the RNAi-cap, a new technology invented at Riboxx. The RNAi-cap technology offers several advantages:
- directional modulation of RISC unwinding of miRNA duplex, enhancing loading of the guide strand to the RISC complex. As a consequence, much less miRNA is needed for an effective gene silencing with a subsequent reduction of off-target effects 
- improved stability of miRNA duplex with subsequent improved half-life in body fluids.
 Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.
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Most recent citations
Parsi S et al. Mol Ther Nucleic Acids. 2015 Oct 6.