CONmiR mimic box

In order to make gene knockdown experiments easier and more effective, Riboxx offers the CONmiR mimic box. The CONmiR mimic box is a powerful all-in-one solution with a package of perfectly matched tools for every step of gene knockdown experiments. It includes 1 x pre-designed CONmiR mimic, 1x CONmiR mimic negative control, and riboxxFECT transfection reagent.

CONmiR mimic displays the RNAi-cap, a new technology invented at Riboxx. The RNAi-cap technology offers several advantages:

• directional modulation of RISC unwinding of miRNA duplex, enhancing loading of the guide strand to the RISC complex. As a consequence, much less miRNA is needed for an effective gene silencing with a subsequent reduction of off-target effects [1]
• improved stability of miRNA duplex with subsequent improved half-life in body fluids.

References
[1] Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.