CONmiR mimic biotin
1 x pre-designed miRNA mimic linked to biotin for potent gene knockdown
Amount: 2, 5 or 10 nmol
Functional group: Biotin
Quality control: PAGE
CONmiR mimic biotin is a miRNA mimic coupled to a biotin.
CONmiR mimics display the RNAi-cap, a new technology invented at Riboxx. The RNAi-cap technology offers several advantages:
- directional modulation of RISC unwinding of miRNA duplex, enhancing loading of the guide strand to the RISC complex. As a consequence, much less miRNA is needed for an effective gene silencing with a subsequent reduction of off-target effects 
- improved stability of miRNA duplex with subsequent improved half-life in body fluids.
 Nolte A, Ott K, Rohayem J, Walker T, Schlensak C, Wendel HP. Modification of small interfering RNAs to prevent off-target effects by the sense strand. N Biotechnol. 2013 Jan 25;30(2):159-65.
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Most recent citations
Parsi S et al. Mol Ther Nucleic Acids. 2015 Oct 6.